DelthaPROST ® 20 Tablets

Composition: 1 tablet
PEA 300,00 mg
N-Acetylcysteine 300,00 mg
Meriva®- Turmeric phospholipid 100,00 mg
– Curcuminoids 18,00 mg
Polygonum extract 52,00 mg
– Resveratrol 50,00 mg
Teupol 10P 50,00 mg
– Teupoliside 5,00 mg
Pumpkin seeds d.e. 10,00 mg

Food supplement containing Teoside, Palmitoylethanolamide (PEA), NACetylcysteine, Resveratrol and phytosomal Turmeric (Meriva) and pumpkin seeds.

Teoside (Teupolioside, Lamiuside A)

delthaPROST® contains Teoside, extracted from plant stem cell cultures of Ajuga reptans (50 mg) titrated to 10% (Teoside: 5 mg). The Ajuga reptans or Erba di San Lorenzo is a herbaceous plant already known in folk medicine employing its leaves and flowers for its outstanding medicinal properties. It was in fact used to fight feverish states, hemorrhages, ulcerations, skin and biliary diseases, bacterial and fungal infections. The active ingredient was identified in the phenylpropanoid TEOSIDE, a secondary metabolite that the plant produces for defensive purposes. The criticality related to this raw material consists in the small quantity of Teoside obtainable by conventional extraction from the whole plant. Moreover, given the complexity of the molecule, chemical synthesis is also inconvenient. To overcome these problems, plant cell stem cell culture technology has been employed, and Teoside has been the first ingredients to be produced (Del Toso R et al., Biotechnology in the production of plant ingredients. The nutritional supplement 2009; 12 (2) : 17-25). Totipotent cells native to Ajuga reptans and absolutely non-GMO are used. Thanks to this technology, TEOSIDE has been classified and has been the first approved for food use as Novel Food: “new” food or ingredients regulated according to the EC Reg. 258 of 1997.
The advantages of cell cultures lie in the production of the active ingredient in a desired and standardized quantity, independent of seasonality and of high purity (absence of heavy metals, pesticides, environmental contaminants) and without affecting natural and environmental resources.
The biological properties of TEOSIDE have been studied in vitro and in vivo, resulting in antioxidant activity (inactivation of free radicals), anti-inflammatory (inhibition of nitric oxide production, protective effect on the inextinal wall in models of colitis), 85% inhibition 5α-reductase enzyme activity (reduction of testosterone conversion in the active form of dihydrotestosterone).

Palmitoiletanolamide (PEA)

delthaPROST® contains PEA (300 mg), a molecule with a powerful anti-inflammatory and analgesic effect. Discovered in 1957, the mechanism of action was clarified in 1993 by Nobel laureate Rita levi Montalcini who coined the term ALIA (Autacoid Local Inflammation Antagonism) to explain its action. In fact, PEA is able to down-modulate mast-cells degranulation at the site of inflammation with reduction of oedema, pain and inflammation itself. The mast-cell is normally found in the tissues, in anatomical-functional connection with vascular structures and nerve endings and if stimulated, free the contents of cytoplasmic granules containing cytokines such as IL1, IL6, IL10 and TNFα, with a pro-inflammatory effect and pain. It therefore acts as an initiator and perpetuator of inflammation and related tissue damage. PEA, present in eggs, soy peanuts and physiologically produced by the body for enzymatic degradation of N-acylphosphatidylethanolamide from plasma membranes, contains this process, however it is not uncommon to see a limited availability of endogenous PEA and a mast-cell “hyperactivation”, with unsatisfactory control of the inflammatory focus, and both inflammatory and neuropathic hyperalgesia.

N-Acetilcisteina (NAC)

N-Acetylcysteine (NAC: 300 mg)) is an N-acetyl derivative of cysteine that contains sulfur. The presence of sulfur endows it with peculiar biological activities, such as the antioxidant and mucolytic ones, particularly appreciable in the event of congestion. As an antioxidant, it is believed that NAC is able to enhance the Glutathione (GSH) system and that together stimulate the activity of T lymphocytes and macrophages with benefits on immunomodulation. About the most known activity of NAC, it acts as a mucolytic and fluidizing secretion thanks to the presence of a free thiol group (SH) that can separate the disulfide bridges characteristic of the cyclic mucoproteins, inhibiting their aggregation and reducing the viscosity of the mucus and facilitating drainage. Furthermore, the NAC also acts on the purulent component of the secretions thanks to its ability to depolymerize the nucleic acids. The destructuring and inhibiting effect of bacterial biofilm is also important. Biofilms are protective structures that bacteria create to protect themselves from antibiotics, survive and perpetuate their presence in various districts, thus constituting a source of annoying recurrences. Many studies have studied and confirmed that taking NAC is a non-pharmacological strategy to fight these infections.
Lastly, the NAC contained in Delthaprost is obtained by fermentation and not from animal sources.

Resveratrol

delthaPROST® contains Polygonium cuspidatum, a perennial herbaceous plant of ancient origin, having also been found traces of fossils dating back to the Tertiary. The rhizomes, or underground roots, are among the richest natural sources of Resveratrol, containing an amount 400 times higher than grapes and derivatives. In Delthaprost there is a dry extract of the Poligonium root (52 mg) titrated to 98%, from which Resveratrol: 50 mg. In combination with the other active components (hemodyn and polydatin) able to increase its bioavailability, the phytocomplex of Polygonium cuspidatum shows marked anti-inflammatory and antioxidant, modulates the metabolism of arachidonic acid and nitric oxide, is appreciated for its anti-aging and studied for its anti-mutagenic, antiproliferative and anti-tumor potentials.

Curcuma

delthaPROST® contains a particular Curcuma, formulated with soy lecithin, called Meriva. The active ingredient of turmeric is curcumin, known and used since ancient times for its extraordinary anti-inflammatory, antioxidant and pain-relieving properties, the latter thanks to its ability to act specifically on nociceptors, ie on the terminations of sensory neurons that signal tissue damage and allow painful sensations to be transmitted to the brain. Recent studies also document its antitumor and cardioprotective activity (source: Effects of Curcuminoids on Frequency of Acute Myocardial Infarction After Coronary Artery Bypass Grafting-journal of Cardiology). It is necessary, however, to underline that curcumin is not the only active ingredient of Curcuma, in it there are two other equally important active ingredients: Demetossicurcumin and Bisdemetossicurcumina, which have therapeutic properties comparable to curcumin itself. Therefore, we speak, more appropriately, of Curcuminoids.
Extractive curcumin has some critical aspects, including two particularly important ones: a low intestinal absorption and a high hepatic first pass metabolism (destruction of the active ingredients during the passage of the same through the liver, before reaching the systemic blood circulation). These problems make the extractive curcumin not very bioavailable and, consequently, prevent the active ingredients from fully carrying out their therapeutic activity in the organism.
To overcome this problem in the Delthaprost, Meriva® is used: curcumin phytosome® (100 mg, titrated 18% in curcuminoids: 18 mg). Phytosomes (from the Greek, phytón: PLANT and soma: BODY) are plant-based complexes that bind curcumin (and other curcuminoids) to phospholipids capable of improving the bioavailability of the active ingredient. Meriva® allows to convey curcumin and the other two curcuminoids so that, through pinocytosis (modality of penetration of the molecules inside the cell), they can enter intestinal cells (enterocytes) and be conveyed into the lymphatic circulation thus bypassing the first pass metabolism hepatic. In this way the 3 curcuminoids will be able to enter the systemic blood circulation reaching directly the sites of action where they will carry out their activity.
It is for these reasons that phytosomal Curcuma guarantees an absorption about 30 times greater than that not formulated.

Pumpkin seeds

The pumpkin is the fruit of a plant belonging to the Cucurbitaceae family and is native to Central and South America. The tribes of the Native Americans but also the Chinese knew its properties and used it as a natural remedy to eliminate intestinal worms. It was likewise known to act positively on the urinary tract, both to maintain the bladder muscle tone and to fight urinary tract inflammation, to provide relief in case of cystitis and to counteract prostate enlargement and benign prostatic hypertrophy symptoms (Continued use of pumpkin seeds oil reduces prostate hypertrophy symptoms by up to 80% with initial results within a few weeks).
Pumpkin seeds have a high biological value as they are rich in monounsaturated and polyunsaturated essential fatty acids (oleic acid, linoleic acid, omega-3), minerals such as phosphorus, magnesium, iron, manganese, copper and zinc, vitamins (B, C, E, K), tryptophan (precursor of serotonin, “the good mood hormone”), cucurbitin (amino acid with vermifuge properties) and betasterols.
Specifically, in vitro and in vivo studies have shown that pumpkin seeds inhibit the growth of prostate cells, reduce BPH-related symptoms and decrease prostate volume. These effects are due to the content of Zinc and phytosterols such as beta sitosterol, sitostanol, avenasterol whose structure is very similar to that of the androgen and estrogen hormones. This confers the ability to inhibit the conversion of testosterone into dihydrotestosterone (thanks to the enzyme 5 Alfa Reductase), responsible for the prostate volume increase.

We recommend taking 1 tablet a day or as prescribed by a doctor, preferably during meals, better not rich in fat; therefore, generally recommended at breakfast.

• When is it recommended to take delthaPROST®? One tablet a day for the well-being of the male urinary tract and prostate gland function.
• Is it preferable to take delthaPROST® on an empty or full stomach? During meals that are preferably not rich in fat, therefore generally recommended at breakfast.
• Does it contain gluten and lactose? No, delthaPROST® does not contain gluten and lactose.
• For how many consecutive months can delthaPROST® be taken? The average duration of a treatment is a cycle of 2-3 months, which may be repeated depending on the advice of the doctor who will assess the clinical condition and therefore whether to continue or repeat the cycle after an interval